No comments about Practical Guide to Interpretive Near-Infrared Spectroscopy.

1 comments about A Beginner's Guide to Mass Spectral Interpretation.

1. Terrence Lee's book title, "A beginners guide to Mass Spectral Interpretation" is quite accurate. It is an excellent source of information for the mass spec novice. It is well written and he also stresses pitfalls students routinely make in analysis. I would recommend this book to any beginner,(undergraduate, graduate or whomever), it makes climbing the learning curve easier. Three thumbs up!.

3 comments about Protein Sequencing and Identification Using Tandem Mass Spectrometry.

1. Michael Kinter has presented the topic in a scientific yet enjoyable format. I found the information to be extremely interesting and beneficial in my laboratory. Lets face it folks this isn't the easiest nor most interesting topic to write about. Job well done DR. Kinter. I only have one criticism, there should have been more photos and illustrations. Get your copies quick this will no doubt be on the NewYork times best seller list before long.



2. I'm not a bench chemist, but I needed a quick survey of how mass spectroscopy is used in handling proteins and other big biomolecules. This book was it.
   
   Although brief, it is thorough and well-organized. The first two chapters are mostly an introduction. Chapter 1 states the problem being solved. The next chapter briefly introduces older technologies, including chemical techiques and 60s-80s mass spec technique. The next two chapters summarize modern mass spec hardware, then start to show how proteins behave in the environment inside the instrument. That gives the fundamentals of protein sequencing: how the molecules break down, and how the fragments help recreate the molecule. The authors go through a few examples in detail, starting from a mass spectrogram and moving forward to sequence. I was especially impressed by the examples that fail. Mass spec analysis is not a magic wand for producing sequences, it is a deductive process, and can not complete an analysis when clues are missing or ambiguous.
   
   The next three chapters are not about mass spec directly. Instead, they discuss how samples are prepared for analysis. This includes the clearest, most informative description of gel electrophoresis that I've seen, along with features of gel chemistry that do or do not interfere with mass spec measurements. This includes a discussion of protein digests, enzymatically produced fragments, and their place in analysis. I would have liked a little more discussion about combining information from digests produced by different enzymes, but no book can cover everything.
   
   The last three chapters extend the discussion of analysis, working upwards from fragments to complete protein sequences. The three chapters respectively address three topics: using standard internet databases for recognizing fragments of known proteins, using combinations of strategies to analyze novel proteins, and using mass spec to identify post-translational modifications. That last one suffers from brevity; perhaps it was only meant to define a problem that deserves a whole book of its own.
   
   Despite its throughness, the authors resist the urge for boggling detail. They present detail up to the point needed for understanding the mechanism and meaning of their topics, then stop. Lots of other writing would benefit from that kind of restraint.
   
   I came away from this book well-informed, and ready to address specific topics in greater detail. That was exactly what I wanted. I recommend this book very highly.
   
   //wiredweird



3. Ao ler esse livro pude perceber que existe variadas técnicas que auxiliam na interpretação dos espectros de massas. A obra descreve os métodos de ionização e a formação dos íons moleculares e quasi-moleculares em cada um desses métodos. O livro tras a interpretação da distribuição de isótopos nas amostras, a identificação dos "parent ions", "base piks" e a distribuição das cargas durante a interpretação dos espectros. A interpretação de sequências de aminoácidos durante a análise de peptídios é rica em dicas, tabelas e exercícios resolvidos. De forma clara é possível entender a lógica por tras da formação das séries de íons A, B, C, X, Y e Z tão importantes durante a identificação da estrutura primária dos peptídeos. Se você pretende trabalhar com a identidficação de compostos de origem protéica utilizando espectrometria de massas, esse deverá ser seu livro de cabeceira!

No comments about Exploring the Spectrum.

2 comments about The Expanding Role of Mass Spectrometry in Biotechnology, Second Edition.

1. Whether you are a biochemist working in the field of biotechnology, or an analytical instrument engineer, Siuzdak's compact text makes for easy reading and a quick way to bone up on most of the MS techniques being used today in biotechnology.
   
   The second edition is a big improvement--better illustrations and graphics (especially the ones for ESI-MUX, high throughput analysis and MALDI and Q-TOF.) Just about every technique and instrument type were covered except for a couple of rare ones I could think of. The range of chapters covers the mass analyzer types then covers the use of various analyzers in pharmacokinetics, molecular analysis, proteins, peptides, nucleic acids and carbohydrates, and high throughput screening.
   
   If you are a professor of analytical chemistry, I would recommend Siuzdak's book for your class. It is well-written, easy to read and covers the subject well. This book would be a welcome desk reference for most scientists who use the services of a mass spectroscopist for their work. There are a few articles on mass spec analysis of steroids, its use in disease diagnosis and a good glossary in the back. Highly recommended as a good basic text.



2. Easy to understand, give the useful information for who are not familiar with MS and if you are graduate student who taking MS class, you have to read this book.

4 comments about Understanding NMR Spectroscopy.

1. Dr. Keeler's is called "Understanding NMR spectroscopy", and that is exactly what it will help you do. He makes very few assumptions about previous knowledge of math and quantum physics. He explains abstract concepts using good analogies. I have tried to read multiple NMR textbooks, and this is by far the most readable... Excellent work Dr. Keeler.... However you should realise what this book is NOT. It is not about how to record and analyze NMR data and it is not an advanced textbook, but aimed for people new to the field with need to understand how an NMR experiment works.



2. Keeler's book is a very clear exposition of the physical basis and quantum mechanical underpinnings of modern NMR experiments. Because it is fundamentally based on the quantum mechanics, it is, I feel, a better introduction to heteronuclear NMR than the popular book by Claridge. At the same time, Keeler avoids the dense pages of mathematics that can make Cavanagh et al.'s excellent book intimidating to students who are not experts on quantum mechanics. An additional plus for me was Keeler's refreshingly clear description of the physical origins of T2 relaxation.
   
   At the same time, there are some deficiencies here. Keeler does not go into chemical exchange effects in any depth, and I do not believe he mentions REX at all. There is also no discussion of residual dipolar couplings, the model-free dynamics formalism, or diffusion experiments. Pulsed-field gradients and phase-cycling are presented almost as an afterthought. The discusisons of coherence order and raising/lowering operators leave something to be desired and the later chapters in which they appear are structured awkwardly. Keeler deals exclusively with dipolar systems in liquids, limitations that may make this text inappropriate for some labs.
   
   That said, for someone who's had some exposure to NMR (in, say, an organic chemistry course) this is an excellent, clear tour of some theoretical NMR basics that can provide a useful framework for approaching more comprehensive texts. Graduate students without a stong background in physical chemistry who intend to perform advanced work in NMR may find this book particularly helpful.



3. Informative and insightful, but assumes a certain foreknowledge of NMR techniques. An excellent resource for people with a working knowledge of NMR who want to improve their fundamental understanding of the technique. Not recommended for those who need a more rudimentary introduction to NMR.



4. This book grew out of a series of lecture notes for various summer schools and graduate courses. The original lecture notes can be downloaded from the web. For several years, I was reluctant to buy this book because I thought the lecture notes from the web and the book are not much different. How wrong can I be. The web version contains a number of typos and several sections are not numbered correctly. The book is virtually free from typos and the presentation is much better. You can read from the book that the author has a lot of teaching experience. Although the book mainly deals with the theoretical aspects of the modern nmr, the math to understand the book is only freshman math. The only math that you need is:
   
   Trigonometry of compound angles and half angles
   Simple first order differential equation
   Simple manipulation of complex numbers
   Operator algebra, and
   Elementary matrix algebra
   
   Do not be intimidated by the math. All the math, except matrix, that is needed can basically be found in Appendix A. There is nothing complex in the math used throughout the book. All the mathematical manipulations are presented in a step by step fashion. The book deals mainly with the most popular nmr techniques such as COSY, DQF-COSY and NOE. Because the book focuses on the theoretical aspects of nmr, it hardly touches on any spectrum interpretations. Sometimes, I feel the book a little bit dry. Virtual coupling, an important concept in TOCSY, is not discussed in Keeler's book. However, do not get me wrong. This is a book I enjoy reading very much. The chapters on relaxation and coherence transfer pathway, phase cycle and pulsed of field gradient are well presented.
   
   How does this book compare with other nmr books? Compare with Neil Jacobsen's book "NMR Spectroscopy Explained", I still like
   Jacobsen's book more. Jacobsen's book is more detailed and contains a lot more information. Furthermore , it covers spectrum interpretation and dynamic nmr. Anyone seriously interested in nmr spectroscopy should have this and Jacobsen's books in his/her library.
   
   You may ask; How about Levitt's book " Spin Dynamics". I have never read this book. The second edition of this book just came out in April this year. I bought a copy and Levitt's book will be my reading project for this summer (over 700 pages).

No comments about Fundamentals of Contemporary Mass Spectrometry (Wiley - Interscience Series on Mass Spectrometry).

1 comments about NMR Spectroscopy Explained: Simplified Theory, Applications and Examples for Organic Chemistry and Structural Biology.

1. Initially I wanted to write a review for this book after I finish the whole book. However, since the publication of this book, I have noticed that nobody has ever written a review. I have only finished approximately 400 pages but I want to let people to know that this is clearest exposition on modern nmr spectroscopy I have ever come across. I have read a number of nmr books. These include the following
   
   J.D. Roberts "ABC of FT NMR"
   T. Claridge "High Resolution NMR spectroscopy in organic chemistry"
   J. Sanders " Modern NMR spectroscopy"
   H. Friebolin "Basic One- and Two-Dimenionsal NMR"
   
   None of the above is as good as this book. The one that comes close to this is Friebolin's book. However, it is not as detail and does not cover topics such as operator formalism and density matrix. This book also covers the basic theoretical principles and presented in a very lucid way. I enjoy reading this book tremendously.

2 comments about Practical Gamma-ray Spectroscopy.

1. Gilmore and Hemingway provide the spectrometer user with the wealth of their years experience in assaying gamma samples. Everything from how to set up a germanium crystal spectrometer, how to calibrate, how to count, and how to document for universal acceptance. This is one-stop shopping for gamma spectrometry...including a comprehensive references list at the end of every chapter that provides the reader with their money's worth from this volume.



2. A must for any practitioner of gamma-ray spectrometry. This 2nd edition has useful updates, including discussion of Digital Signal Processors (DSP, which to an old timer like me are marvelous innovations). The author provides lucid explanations of everything from how superior-resolution Ge detectors are manufactured to the statistical nuances of spectral data processing. Such a deal!

1 comments about Basic One- and Two-Dimensional NMR Spectroscopy.

1. As a student who doesn't always understand what they're talking about, this book was wonderful. Very clear, very easy-to-understand language. Thanks!