1 comments about A Beginner's Guide to Mass Spectral Interpretation.

1. Terrence Lee's book title, "A beginners guide to Mass Spectral Interpretation" is quite accurate. It is an excellent source of information for the mass spec novice. It is well written and he also stresses pitfalls students routinely make in analysis. I would recommend this book to any beginner,(undergraduate, graduate or whomever), it makes climbing the learning curve easier. Three thumbs up!.

1 comments about Scanning Probe Microscopy and Spectroscopy: Theory, Techniques, and Applications.

1. This book mainly focus on STM. However, it doesn't cover much on AFM. The use of AFM has become increasingly popular in recent years in research investigation in various areas, including cell biology, DNA research, material science, nanotechnology, and so on. The editor may consider include detailed discussion on AFM in next edition (if any).

2 comments about Quality Assurance of Chemical Measurements.

1. This book is a valuable reference for quality managers and analysts in the laboratory. It covers many topics concerning quality assurance, and is easy to read and understand. It offers a good overview of the principals involved in a laboratory quality program.



2. This is easily the best reference I have found for general QA/QC practices in testing laboratories. If you have one reference in your library this should be it. I have been cracking the cover on this one since the early eighties.

3 comments about Protein Sequencing and Identification Using Tandem Mass Spectrometry.

1. Michael Kinter has presented the topic in a scientific yet enjoyable format. I found the information to be extremely interesting and beneficial in my laboratory. Lets face it folks this isn't the easiest nor most interesting topic to write about. Job well done DR. Kinter. I only have one criticism, there should have been more photos and illustrations. Get your copies quick this will no doubt be on the NewYork times best seller list before long.



2. I'm not a bench chemist, but I needed a quick survey of how mass spectroscopy is used in handling proteins and other big biomolecules. This book was it.
   
   Although brief, it is thorough and well-organized. The first two chapters are mostly an introduction. Chapter 1 states the problem being solved. The next chapter briefly introduces older technologies, including chemical techiques and 60s-80s mass spec technique. The next two chapters summarize modern mass spec hardware, then start to show how proteins behave in the environment inside the instrument. That gives the fundamentals of protein sequencing: how the molecules break down, and how the fragments help recreate the molecule. The authors go through a few examples in detail, starting from a mass spectrogram and moving forward to sequence. I was especially impressed by the examples that fail. Mass spec analysis is not a magic wand for producing sequences, it is a deductive process, and can not complete an analysis when clues are missing or ambiguous.
   
   The next three chapters are not about mass spec directly. Instead, they discuss how samples are prepared for analysis. This includes the clearest, most informative description of gel electrophoresis that I've seen, along with features of gel chemistry that do or do not interfere with mass spec measurements. This includes a discussion of protein digests, enzymatically produced fragments, and their place in analysis. I would have liked a little more discussion about combining information from digests produced by different enzymes, but no book can cover everything.
   
   The last three chapters extend the discussion of analysis, working upwards from fragments to complete protein sequences. The three chapters respectively address three topics: using standard internet databases for recognizing fragments of known proteins, using combinations of strategies to analyze novel proteins, and using mass spec to identify post-translational modifications. That last one suffers from brevity; perhaps it was only meant to define a problem that deserves a whole book of its own.
   
   Despite its throughness, the authors resist the urge for boggling detail. They present detail up to the point needed for understanding the mechanism and meaning of their topics, then stop. Lots of other writing would benefit from that kind of restraint.
   
   I came away from this book well-informed, and ready to address specific topics in greater detail. That was exactly what I wanted. I recommend this book very highly.
   
   //wiredweird



3. Ao ler esse livro pude perceber que existe variadas técnicas que auxiliam na interpretação dos espectros de massas. A obra descreve os métodos de ionização e a formação dos íons moleculares e quasi-moleculares em cada um desses métodos. O livro tras a interpretação da distribuição de isótopos nas amostras, a identificação dos "parent ions", "base piks" e a distribuição das cargas durante a interpretação dos espectros. A interpretação de sequências de aminoácidos durante a análise de peptídios é rica em dicas, tabelas e exercícios resolvidos. De forma clara é possível entender a lógica por tras da formação das séries de íons A, B, C, X, Y e Z tão importantes durante a identificação da estrutura primária dos peptídeos. Se você pretende trabalhar com a identidficação de compostos de origem protéica utilizando espectrometria de massas, esse deverá ser seu livro de cabeceira!

No comments about Handbook of Capillary and Microchip Electrophoresis and Associated Microtechniques, Third Edition.

No comments about Validating Chromatographic Methods: A Practical Guide.

1 comments about Spectroscopy of Polymers, Second Edition.

1. Purists and theoreticians might not like this book, but I found it clear, practical, and a joy to read. This textbook describes all the common spectroscopic techniques used on polymers with a slant toward applications: why you'd use one technique instead of another, what the strengths and weaknesses of each technique are, and what you have to consider differently when working with polymers as opposed to small molecules. The theory is a bit light (usually there's just enough to describe how each technique works), but there are references to the literature if you need more theoretical depth. Perhaps best of all is Koenig's writing style, which makes even discussions of NMR pulse sequences fun to read (I had the pleasure of taking a course with Dr. Koenig before he retired, and his dark sarcasm and anecdotes made a potentially numbing class quite enjoyable). If he could have generalized this book to include subjects other than polymers and plastics (e.g. biophysics and environmental chemistry), it would have become a classic.

1 comments about Handbook of Process Chromatography, Second Edition: Development, Manufacturing, Validation and Economics.

1. This book bascially takes you through day 1 of drug manufacturing all the way to the end, when you have deal with regulatory. It also discusses analytical methods which was of great interest to me. Highly recommended for anyone who wants to learn more about this field.

No comments about Principles of Thermal Analysis and Calorimetry (RSC Paperbacks).

No comments about Flow Cytometry for Biotechnology.